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为了探讨日本血吸虫病患者杀虫治疗后肝纤维化的变化，对粪检阳性日本血吸虫病患者，用吡喹酮治疗后一年，观察５５例粪检复查阴性者治疗前，后腹部Ｂ超及血清透明质酸（ＨＡ）、Ⅲ型前胶原（ＰＣⅢ）的变化，ＨＡ与ＰＣⅢ均用ＲＩＡ法。结果显示，腹部Ｂ超检查门脉Ⅱ级分支外径（Ｄ）与内径（ｄ）比值由２．１５±０．３２降至１．８９±０．２４，治疗前、后差异有显著性（Ｐ＜０．０１）；治疗后肝左叶长径、肝右叶长径（Ⅰ）、脾脏长径均有明显缩小（Ｐ＜０．０５）。与自然人群比较治后肝左叶厚度，肝右叶最大斜径、脾脏长径、脾脏指数、门脉主干内径及Ｄ／ｄ比值仍有显著差异，治后肝纤维化血清指标ＨＡ、ＰＣⅢ阳性率分别由３５．４％和７１．７％降至１４．９％和２２．５％，其差异均有非常显著意义。本研究提示经吡喹酮治疗后一年，肝纤维化程度有好转，但未达正常人水平。
In order to investigate the changes of hepatic fibrosis after insecticide treatment in schistosomiasis japonica, one year after treatment with praziquantel in patients with positive schistosomiasis japonica, 55 cases with negative stool examinations before and after treatment were observed. Serum hyaluronic acid (HA), type Ⅲ procollagen (PC Ⅲ) changes, HA and PC Ⅲ are used RIA method. The results showed that the ratio of external diameter (D) to internal diameter (d) of grade B branch of abdominal ultrasound examination decreased from 2.15 ± 0.32 to 1.89 ± 0.24, there was significant difference before and after treatment P <0.01). After treatment, the diameter of the left lobe, the diameter of the right lobe (Ⅰ) and the diameter of the spleen were significantly reduced (P <0.05). Compared with the control group, the thickness of the left hepatic lobe, the largest oblique diameter of the right lobe, the diameter of the spleen, the spleen index, the diameter of the portal vein and the ratio of D / d were still significantly different after treatment. The serum markers of HA and PCⅢ The rates dropped from 35.4% and 71.7% to 14.9% and 22.5%, respectively, with significant differences. This study suggests that one year after praziquantel treatment, liver fibrosis improved, but did not reach the normal level.