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目的:研究补锌去铁对中药抗鸭乙型肝炎病毒(DHBV)的作用。方法:用垂直传播的DHB阳性的6月龄麻鸭作为实验动物模型,随机分为4组,另取同品系同月龄的DHBV阴性麻鸭作为正常组。现察给药后各组的ALT,AST,DHBVDNA,血清锌、血清铁和肝组织铁浓度。结果:中药补锌去铁组与中药组比较,其降ALT,AST,DHBVDNA更显著(P<0.01),其血清锌明显高于中药组(P<0.01),血清铁、肝组织铁浓度明显低于中药组。结论:补锌去铁能增强中药抗DHBV的作用。
Objective: To study the effect of zinc supplementation and iron removal on duck hepatitis B virus (DHBV). METHODS: Vertically spread DHB-positive 6-month-old ducks were used as experimental animal models and randomly divided into 4 groups. The same group of DHBV-negative ducks of the same age were used as the normal group. ALT, AST, DHBV DNA, serum zinc, serum iron, and liver tissue iron concentrations were observed in each group after administration. RESULTS: Compared with the traditional Chinese medicine group, the zinc supplementation group of traditional Chinese medicine supplemented with zinc had more significant decrease in ALT, AST, and DHBV DNA (P<0.01). The serum zinc was significantly higher than that of the traditional Chinese medicine group (P<0.01). The serum iron and liver tissue iron concentrations were significantly increased. Lower than the Chinese medicine group. Conclusion: Zinc-free iron can enhance the anti-DHBV effect of traditional Chinese medicine.