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目的探讨艾司西酞普兰并富马酸喹硫平治疗伴有躯体化症状抑郁症的临床疗效及安全性.方法将80例抑郁症患者随机分成两组各40例,研究组应用艾司西酞普兰并喹硫平治疗,对照组单用艾司西酞普兰治疗,总疗程6周.应用17项汉密尔顿抑郁量表(HAMD-17)、14项汉密尔顿焦虑量表(HAMA-14)评定疗效,不良反应量表(TESS)及有关实验室检查评定不良反应.结果治疗6周后,研究组有效率为92.5%,与对照组比较差异有显著性(P <0.05).两组治疗后HAMD、HAMA评分比较差异有显著性(P 0.05),不良反应轻微.结论艾司西酞普兰合并喹硫平治疗伴躯体化症状的抑郁症安全、有效,值得临床推广使用.“,”Objective To study the efficacy and safety of escitalopram combined with quetiapined in the treatment of depression with physical symptoms. Methods The 80 patients with depression were randomly divided into 2 groups(40 patients in escitalopram combined with quetiapined group, 40 patients in escitalopram group), The course was 6 weeks. Clinical effectiveness was evaluated using HAMD-17, HAMA-14, and adverse reactions and safety were assessed with TESS and laboratory examination. Result In the end of the treatment, the response rate was 92.5% for escitalopram combined with quetiapined group, there was significant difference of the efficacy(P <0.05). The difference in HAMD and HAMA score after treatment was significant(P 0.05). Conclusion Escitalopram combined with quetiapine for depression with physical symptoms is an effective and safe therapy.