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目的探讨启肝毓坤汤治疗卵巢早衰患者的临床疗效。方法选择卵巢早衰患者85例,随机分为两组,其中治疗组46例,对照组39例,对照组用西药雌孕激素序贯疗法,治疗组用启肝毓坤汤,两组均连续治疗3个月,治疗前后采血。对比治疗前后临床症状、雌二醇(E_2)、卵泡刺激素(FSH)、促黄体生成激素(LH)水平的差异。结果治疗组总有效率为89.13%(41/46例),对照组为79.49%(31/39例),两组比较差异有统计学意义(P<0.05)。两组病例经过治疗后,腰酸坠胀症状消失率优于对照组(P<0.05)。两组血清FSH、LH、E_2值治疗前后比较,差异有统计学意义(P<0.05);治疗后血清E_2水平优于对照组(P<0.05),而治疗后两组间FSH、LH的水平无统计学差异(P>0.05)。结论启肝毓坤汤可以有效改善由卵巢早衰引起的激素变化,且能缓解临床症状,临床疗效较好。
Objective To investigate the clinical efficacy of Qigan Yukun Decoction in treating patients with premature ovarian failure. Methods 85 cases of premature ovarian failure were randomly divided into two groups, including 46 cases in the treatment group and 39 cases in the control group. The control group was treated with sequential therapy of estrogen and progesterone, the treatment group was treated with Qigan Yukun Decoction, and both groups were treated continuously 3 months, before and after treatment blood. The differences of clinical symptoms, estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH) before and after treatment were compared. Results The total effective rate was 89.13% (41/46 cases) in the treatment group and 79.49% (31/39 cases) in the control group. The difference between the two groups was statistically significant (P <0.05). Two groups of patients after treatment, backache bulge symptoms disappeared more than the control group (P <0.05). Serum levels of FSH, LH and E_2 in the two groups before and after treatment were significantly different (P <0.05); serum E_2 level was better than the control group after treatment (P <0.05), but after treatment, the levels of FSH, LH No statistical difference (P> 0.05). Conclusion Qigan Yukun Decoction can effectively improve hormone changes caused by premature ovarian failure, and can relieve clinical symptoms, clinical efficacy is better.