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Objective. - To investigate the 5- HTT- gene- linked polymorphic region (5- HTTLPR) genotypes and harm avoidance (HA) dimension in chronic tension- type headache (CTH). Background. - Serotonin transporter protein (5- HTT) is a key modulating protein in synaptic serotonergic neurotransmission. Among serotonin gene- linked polymorphism, promoter located in the regulatory region of the 5- HTTLPR has two alleles (short and long) with different transcriptional efficiencies. The HA personality trait may be heritable and associated with serotonergic neurotransmitter activity. Design. - We amplified the 5- HTTLPR by means of polymerase chain reaction and performed genotype polymorphism analyses and we investigated the serotonin- related personality trait by evaluating the HA dimension in tridimensional personality questionnaire (TPQ) in 107 patients with CTH and in 100 healthy controls. Results. - We found an excess frequency of the short allele and a different genotype distribution in patients with CTH. S/S genotype frequency was significantly higher in patients with CTH (76% )- than in those with controls (59% ; P= .02). Patients with CTH had significantly higher HA scores (21.4 ± 6.3) than controls (16.3 ± 6.1). Conclusions. - This suggests a serotonergic activity might be involved in the development of CTH and 5- HTTLPR might be one of the genetically contributing factors.
To investigate the 5-HTT-gene-linked polymorphic region (5-HTTLPR) genotypes and harm avoidance (HA) dimension in chronic tension-type headache (CTH). Background. - Serotonin transporter protein (5- HTT) is a key modulating protein in synaptic serotonergic neurotransmission. Among serotonin gene-linked polymorphisms, promoter located in the regulatory region of the regulatory region of the 5-HTTLPR with two alleles (short and long) with different transcriptional efficiencies. The HA personality trait may be heritable and associated with Design of - - amplified 5-HTTLPR by means of polymerase chain reaction and genotype polymorphism analyzes and we investigated the serotonin-related personality trait by evaluating the HA dimension in tridimensional personality questionnaire (TPQ) in 107 patients with CTH and in 100 healthy controls. Results. - We found an excess frequency of the short allele and a different genotype distribution in patient s with CTH. S / S genotype frequency was significantly higher in patients with CTH (76%) - than in those with controls (59%; P = .02). Patients with CTH had significantly higher HA scores (21.4 ± 6.3) than controls (16.3 ± 6.1). Conclusions. - This suggests a serotonergic activity might be involved in the development of CTH and 5-HTTLPR might be one of the genetically contributing factors.