针对肽脂质(N+C5G ly2C16)的合成中分离纯化过程复杂,产率太低的问题,对它的合成过程尤其是产物纯化方法进行了改进。对每一步反应都进行了使产率明显提高的改进,尤其是叔丁氧甲酰甘氨酰双十六烷基胺油状物不经纯化即进行分解生成甘氨酰双十六烷基胺三氟乙酸盐。完全用重结晶取代了层析方法进行各步产物的纯化,使合成过程简捷、高效,肽脂质合成规模可以不受纯化方式的限制,合成总产率由2%提高到了23%。 In the synthesis of peptide lipids (N + C5G ly2C16) complex separation and purification process is too complicated, the yield is too low, its synthesis process, especially the product purification method was improved. For each step the reaction has been significantly improved yield improvements, especially tert-butoxycarbonyl glycyl dihexadecylamine oil that is not purified to produce glycyl dihexadecylamine tris Fluoroacetate. Completely recrystallized instead of chromatography method for the purification of each step of the product, so that the synthesis process is simple and efficient, peptide synthesis scale can be free from the limitations of purification methods, the total synthesis rate increased from 2% to 23%.