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目的 观察乳腺癌组织中雌、孕激素受体(ER、PR)与C-erhB-2、p53、nm23基因表达及其相互关系,及乳腺癌淋巴结转移与基因表达关系。方法 应用免疫组织化学方法对85例乳腺癌进行了ER、PR、CerbB-2、p53、nm23检测,结果作统计学分析。结果 (1)ER、PR阳性表达率分别为63.52％和72.94％;(2)C-erbB-2、p53、nm23的表达率各为68.23％、32.94％、63.52％;(3)ER、PR阳性患者的C-erbB-2或p53的阳性表达明显低于ER、PR阴性患者(P<0.05);(4)淋巴结有转移的乳腺癌患者nm23阳性表达明显低于无淋巴结转移的患者(P<0.05),p53表达则在有淋巴结转移者的乳癌中表达高(P<0.01)。结论 ER、PR与C-erbB-2、p53、nm23这两种不同特性产物在乳腺癌组织中有一定的内在联系,p53、nm23的阳性表达对判断乳癌的肿瘤转移及预后有重要意义。
Objective To observe the expression and relationship of estrogen and progesterone receptor (ER, PR) and C-erhB-2, p53 and nm23 genes in breast cancer, and the relationship between lymph node metastasis and gene expression in breast cancer. Methods Immunohistochemistry was used to detect ER, PR, CerbB-2, p53 and nm23 in 85 cases of breast cancer. The results were statistically analyzed. Results (1) The positive expression rates of ER and PR were 63.52% and 72.94%, respectively; (2) The expression rates of C-erbB-2, p53 and nm23 were 68.23%, 32.94% and 63.52% respectively; (3) ER, PR The positive expression of C-erbB-2 or p53 in positive patients was significantly lower than that in ER and PR negative patients (P<0.05); (4) The positive expression of nm23 in breast cancer patients with metastasis was significantly lower than those without lymph node metastasis (P) <0.05), p53 expression was higher in breast cancer with lymph node metastasis (P < 0.01). Conclusions ER, PR and C-erbB-2, p53 and nm23 have different intrinsic linkages in breast cancer tissues. The positive expression of p53 and nm23 is important for judging the metastasis and prognosis of breast cancer.