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目的 分析妊娠早期联合指标对子痫前期的预测价值。方法 本次的研究对象选择2019年10月至2021年9月在我院进行产前检查的孕妇，共2115例。根据是否确诊为子痫前期进行分组，分别为健康组与子痫前期组，并将子痫前期组根据病情分为轻度子痫前期组和重度子痫前期组。分别进行孕妇妊娠早期（孕10~12周）的血清胎盘生长因子（PLGF）、妊娠相关血浆蛋白A（PAPP-A）、甲胎蛋白（AFP）、游离雌三醇（uE3）水平的比较；分析PLGF、PAPP-A、AFP、uE3与孕妇妊娠20周后的血压、24h尿蛋白定量、尿蛋白“,”Objective To analyze the predictive value of combined indicators in early pregnancy for preeclampsia. Methods The subjects of this study selected 2 115 pregnant women who had undergone prenatal check-ups in our hospital from October 2019 to September 2021. According to whether they were diagnosed with preeclampsia， they were divided into healthy group and preeclampsia group， and the preeclampsia group was divided into mild preeclampsia group and severe preeclampsia group according to the condition of the disease. The healthy group and the preeclampsia group， the mild preeclampsia group and the severe preeclampsia group were treated with the serum placental growth factor (PLGF) and pregnancy-associated plasma protein A (PAPP-A) Comparison of alpha-fetoprotein (AFP) and free estriol (uE3) levels; analysis of PLGF， PAPP-A， AFP， uE3 and pregnant women\'s blood pressure， 24 hours urine protein quantitative， urine protein/creatinine ratio after 20 weeks of pregnancy Relevance. And compare the sensitivity， specificity and accuracy of PLGF， PAPP-A， AFP， uE3 alone for predicting preeclampsia and combined for predicting preeclampsia. Results The PLGF， PAPP-A and uE3 of the pregnant women in the preeclampsia group were significantly lower than those in the healthy group (P ＜0.05)， and the AFP was higher than the healthy group (P ＜0.05); the PLGF of the pregnant women in the severe preeclampsia group in the early pregnancy the levels of， PAPP-A and uE3 were lower than those in the mild preeclampsia group (P ＜0.05)， and AFP was higher than that in the mild preeclampsia group (P ＜0.05). PLGF， PAPP-A， uE3 levels were negatively correlated with blood pressure， 24 hours urine protein quantification， and urine protein/creatinine ratio (P ＜0.05)， and AFP levels were positively correlated with them (P ＜0.05). The sensitivity， specificity and accuracy of PLGF， PAPP-A， AFP， and uE3 used to predict pre-eclampsia alone were lower than those used in combination to predict pre-eclampsia (P ＜0.05). Conclusion The combined detection of pregnant women\'s serum PLGF， PAPP-A， AFP， and uE3 levels in early pregnancy has a good predictive value for preeclampsia. It is helpful for early intervention to reduce the incidence of preeclampsia and protect the health of mothers and babies， have a positive impact.