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目的分析 ICU 收治的碳青霉烯类抗生素耐药肺炎克雷伯氏菌（CRKp）感染患者的临床特征及相关危险因素。方法选取2014年1月-2015年6月我院 ICU 收治的 CRKp 感染患者85例，根据药敏试验结果将入选患者分为碳青霉烯类抗生素耐药组48例和碳青霉烯类抗生素敏感组37例，对患者病例特点进行回顾性分析。结果 CRKp感染与抗生素治疗时≥7d、泌尿道病史、患恶性肿瘤、行肾透析、使用头孢类抗菌药物、喹诺酮类抗菌药物显著相关（P ＜0．05），均是碳青霉烯类抗生素耐药肺炎克雷伯氏菌感染的独立危险因素。结论对 ICU 收治的 CRKp感染患者，应在抗感染的同时积极治疗原发病及合并症，密切关注细菌试验及药敏结果，高效利用抗菌药物，尽可能缩短抗生素的应用时长。“,”Objective To analysis the features and factors analysis of klebsiella pneumoniae infection with carbapen_em antibiotic resistance. Methods Selected 85 cases patients with CRKp infections from Jan. 2014 to June 2015. 85 cases pa_tients were divided by susceptibility test results into carbapenem resistant group(48 cases)and carbapenems sensitive group(37 cases). Retrospective analysis of the clinical features of 2 groups. Results CRKp infection was related with antibiotic treat_ment ≥7d,urinary tract,malignancy,renal dialysis,cephalosporin antimicrobial drugs,quinolones(P < 0. 05). Those were in_dependent risk factor of carbapenem_resistant Klebsiella pneumoniae infection. Conclusion CRKp infected patients in ICU should be anti_infection and treat primary disease and complications in the same time. Pay close attention to the bacteria and antimicrobial susceptibility test results,the efficient use of antimicrobial agents,as far as possible to shorten the duration of an_tibiotic use.