论文部分内容阅读
对５６例矽肺患者支气管肺泡灌洗液（ＢＡＬＦ）及ＢＡＬＦ中肺巨噬细胞（ＡＭ）无血清培养上清液中ＴＮＦ含量进行了检测，同时探讨了它们对人胚肺成纤维细胞（ＦＢ）增殖活性的影响。结果表明：ＢＡＬＦ中可疑矽肺ＴＮＦ含量高于其它各期矽肺，随着期别增加而减少。ＡＭ上清液中ＴＮＦ含量Ⅱ期高于Ⅰ期。ＢＡＬＦ和ＡＭ上清液促ＦＢ增殖活性与ＴＮＦ含量高低有一定关系，随着ＴＮＦ浓度增高而增高，但不成平行关系。这可能是矽肺病人ＡＭ释放调节成纤维细胞增殖因子的不仅有ＴＮＦ，而还有其它一些促纤维化因子
The levels of TNF in the serum - free supernatants of bronchoalveolar lavage fluid (BALF) and pulmonary macrophages (AM) in 56 patients with silicosis were detected. The effects of them on the proliferation of human embryo lung fibroblasts (FBs) Effect of proliferative activity. The results showed that TNF in suspicious silicosis in BALF was higher than that in other stages of silicosis, and decreased with the increase of stage. The content of TNF in AM supernatant was higher than that in stage Ⅰ. The activity of FB proliferation induced by BALF and AM supernatant was related to the level of TNF, but increased with the increase of TNF concentration but not in parallel. This may be due to the release of fibroblast growth factor AM released by AM in patients with silicosis not only of TNF, but also of other pro-fibrotic factors