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[目的]观察八珍汤联合羟基脲治疗中老年慢性粒细胞白血病(chronic myelocytic leukemia,CML)的临床疗效。[方法]回顾性分析本院2008年至2012年慢粒患者30例,分为治疗组(15例)予八珍汤联合羟基脲治疗,对照组(15例)予单纯羟基脲治疗,观察其客观疗效、中医症状的变化、血象的变化、生活质量的改善情况及年龄与疗效的相关性的分析总结。[结果]治疗组的完全缓解(Complete remission,CR)率(73.3%)优于对照组(46.7%),治疗组的中医症状缓解率、血象改善情况皆优于对照组,差异有统计学意义(P<0.05),治疗组治疗后卡氏评分增加率(80.0%)优于对照组(53.3%),治疗组的完全缓解率60～70岁(80%)、60～70岁(75%)、>70岁(67%),对照组的完全缓解率60～70岁(50%)、60～70岁(50%)、>70岁(40%),治疗组和对照组的CR率随年龄递增而递减。[结论]八珍汤联合羟基脲治疗中老年慢性粒细胞白血病能够提高临床客观疗效,在一定程度上改善患者疾病的相关症状,提高患者的生活质量。
[Objective] To observe the clinical efficacy of Bazhen Decoction combined with hydroxyurea in the treatment of chronic myelocytic leukemia (CML). [Methods] A retrospective analysis of 30 patients with chronic granulomatosis in our hospital from 2008 to 2012 were divided into treatment group (n = 15) and bazhen decoction combined with hydroxyurea. Control group (n = 15) Objective curative effect, the change of TCM symptom, change of blood picture, the improvement of quality of life and the correlation between age and curative effect. [Results] The complete remission (CR) rate (73.3%) in the treatment group was better than that in the control group (46.7%). The symptom-remission rate and improvement of blood quality in the treatment group were better than those in the control group, the difference was statistically significant (P <0.05). After treatment, the increase rate of card’s score (80.0%) in the treatment group was superior to that of the control group (53.3%). The complete remission rate was 60-70 years (80% ),> 70 years old (67%). The complete remission rate was 60-70 years (50%), 60-70 years (50%) and> 70 years Decreasing with age. [Conclusion] Bazhen Decoction combined with hydroxyurea in the treatment of middle-aged and elderly patients with chronic myeloid leukemia can improve clinical objective curative effect, and to some extent, improve the symptoms of patients’ diseases and improve the quality of life of patients.