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目的:研究穿破石总黄酮对两种肝纤维化模型大鼠的影响。方法:Wistar大鼠分为不同浓度给药组、模型组和空白组。采用两种肝纤维化模型造模,同时给药。8周后,取大鼠血清测ALT和AST,并检测肝脏MDA、SOD的含量。结果:穿破石总黄酮能降低化学损伤模型大鼠血清中ALT和AST的活性,增加SOD活性,抑制MDA的生成。但只提高免疫型肝纤维化模型大鼠的SOD活性。结论:穿破石总黄酮可减轻CCl4所诱导化学损伤的肝纤维化模型大鼠肝损伤程度。
OBJECTIVE: To study the effect of flavonoids in bursa on the hepatic fibrosis in rats. Methods: Wistar rats were divided into different concentrations of drug administration group, model group and blank group. Two models of hepatic fibrosis were used to make the model and administered simultaneously. Eight weeks later, serum from rat was measured for ALT and AST, and the contents of MDA and SOD in liver were measured. Results: The total flavonoids in puncture stone can reduce the activity of ALT and AST in the serum of chemical injury model rats, increase the activity of SOD, and inhibit the production of MDA. However, only SOD activity was increased in immunological liver fibrosis model rats. CONCLUSION: Total flavonoids can reduce the degree of hepatic injury in chemically injured hepatic fibrosis model rats induced by CCl4.