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内皮素(Endotnelin,ET)是首先从猪血管内皮细胞中分离纯化出来的,具有21个氨基酸的生物活性多肽。人的ET可有三种基因表达,即ET-1、ET-2和ET-3,其中以ET-1活性最强。ET具有强烈的收缩冠脉、肾小动脉,刺激心钠素释放,提高全身血压,抑制肾素释放以及缩血管作用。因此ET水平必定与心血管疾病、肾脏疾病等密切相关。 超氧化物歧化酶(Super Oxide dismutase SOD)活性变化可引起体内超氧自由基(O_2~-)的改变。氧自由基直接破坏肾小球,使肾组织代谢障碍,肾小球滤过减少,SOD浓度减少。长期血液透析可有效清除慢性肾衰患者体内某些代谢产物积累,从而减弱对SOD活性抑制,恢复抗氧化能力。为此,本文观察42例慢性肾衰患者血液透析前后ET、SOD浓度改变,并与30例正常成人进行对照,现报告如下。
Endotin (Endotnelin, ET) is a 21 amino acid bioactive polypeptide isolated and purified from porcine vascular endothelial cells. There are three kinds of human ET gene expression, namely ET-1, ET-2 and ET-3, of which the most active ET-1. ET has a strong contraction of the coronary arteries, renal artery, stimulate the release of atrial natriuretic peptide, increase systemic blood pressure, inhibit renin release and vasoconstriction. Therefore, the level of ET must be closely related to cardiovascular diseases and kidney diseases. Changes in the activity of superoxide dismutase (SOD) can cause the change of superoxide radical (O 2 -) in the body. Oxygen free radicals directly damage the glomerulus, renal metabolic disorders, glomerular filtration decreased, SOD decreased. Long-term hemodialysis can effectively remove the accumulation of certain metabolic products in patients with chronic renal failure, thereby weakening the inhibition of SOD activity and restoring the antioxidant capacity. To this end, this paper observed 42 patients with chronic renal failure before and after hemodialysis ET, SOD concentration changes, and 30 cases of normal adults were controlled, are as follows.