Base isolation is one of the most promising alternatives among the structure control methods. In recent decades, base isolation has been seriously considered for civil structures, such as buildings and bridges, subjected to ground motion. The research achievements and development of seismic base isolation technique for civil structures in Huazhong University of Science and Technology (HUST) are introduced. The achievements include project applications, experimental research results and theoretical innovation. Base isolation is one of the most promising alternatives among the structure control methods. In recent decades, base isolation has been seriously considered for civil structures, such as buildings and bridges, subjected to ground motion. The research achievements and development of seismic base isolation technique for civil structures in Huazhong University of Science and Technology (HUST) are introduced. The achievements include project applications, experimental research results and theoretical innovation.