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目的 探讨抗脂肪阿拉伯酸甘露聚糖抗体 (LAM IgG)对儿童肺外结核病的诊断价值。方法 检测 5 2例肺外结核病患儿、4 2例单纯肺门淋巴结结核和 30例非结核病患儿血清或 (和 )体腔液LAM IgG和结核菌纯蛋白衍化物 (PPD)皮试。结果 PPD试验对诊断儿童结核病的特异性为 83 3% (2 5 /30 ) ,但对儿童肺外结核病和单纯肺门淋巴结结核的敏感性分别为 2 8 8%和 90 5 % (χ2 =35 88,P <0 0 1) ;LAM IgG对诊断儿童结核病的特异性为 96 7% (2 9/30 ) ,但对儿童肺外结核病和单纯肺门淋巴结结核的敏感性分别为 6 9 2 %和 9 5 % (χ2 =33 88,P <0 0 1) ;PPD和LAM IgG对儿童结核病的特异性差异无显著性 (χ2 =2 96 ,P >0 0 5 )。结论 LAM IgG对儿童肺外结核病有较好的诊断价值。
Objective To investigate the diagnostic value of anti-fat arabinan mannan antibody (LAM IgG) in children with extra-pulmonary tuberculosis. Methods Serum or (or) body cavity fluid LAM IgG and tubercuin pure protein derivative (PPD) skin test were detected in 52 cases of extrapulmonary tuberculosis, 42 cases of simple hilar lymph node tuberculosis and 30 cases of non-tuberculosis children. Results The specificity of PPD test was 83.3% (25/30) in diagnosing childhood tuberculosis, but it was 28.8% and 90.5% in children with extrapulmonary tuberculosis and simple hilar lymph node tuberculosis (χ2 = 35 88, P <0.01). The specificity of LAM IgG in diagnosis of childhood tuberculosis was 96 7% (29/30), but the sensitivity of LAM IgG to children with extrapulmonary tuberculosis and simple hilar lymph node tuberculosis was 69 2% And 95% (χ2 = 33 88, P <0.01). There was no significant difference in the specificity of PPD and LAM IgG between children with tuberculosis (χ2 = 2 96, P 0 05). Conclusion LAM IgG has a good diagnostic value in children with extra-pulmonary tuberculosis.