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肠黏膜通透性增高被认为是多种肠道疾病发生的先兆,预示着肠黏膜屏障功能障碍。近年来,越来越多研究认为炎症性肠病(IBD)、肠易激综合征(IBS)的发生机制与肠黏膜通透性增高有关。以中医理论的角度考虑,脾为之卫,为后天之本,与机体防御免疫功能存在密切关系。肠黏膜通透性的增高可能与脾气虚、机体防御功能下降、免疫激活相关。该文目的在于探讨肠黏膜通透性增高与IBD、IBS发病机制和脾气虚的关系,寻求疾病治疗的新靶点,从而阻断肠黏膜通透性增高来预防疾病的发生。
Increased intestinal mucosal permeability is considered a precursor to a variety of intestinal diseases, suggesting that intestinal mucosal barrier dysfunction. In recent years, more and more studies suggest that the pathogenesis of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) is related to the increase of intestinal mucosal permeability. Considered from the perspective of TCM theory, spleen is the guard, which is the basis for acquired immunity and is closely related to the body’s defense against immune function. Increased intestinal mucosal permeability may be associated with spleen deficiency, decreased body defense function, immune activation. The purpose of this article is to explore the relationship between the increased permeability of the intestinal mucosa and the pathogenesis of IBD and IBS and the deficiency of the spleen and to seek new targets for disease treatment so as to prevent the increase of intestinal mucosal permeability to prevent the occurrence of the disease.