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目的优选消渴健脾胶囊中挥发油的提取与包合工艺。方法采用水蒸气蒸馏法提取挥发油,以提取量为指标,通过单因素试验考察浸泡时间,加水量、提取时间对提取工艺的影响;采用饱和水溶液法包合挥发油,以包合率为指标,通过正交试验考察挥发油与β-环糊精的比例,包合时间及包合温度对包合工艺的影响。结果最佳提取工艺为加10倍量水提取6h;最佳包合工艺为挥发油与β-环糊精的比例1∶8,包合温度30℃,包合时间1h。结论优选的挥发油提取与包合工艺条件稳定可行。
Objective To optimize the extraction and inclusion technology of volatile oil in Xiaokejianpi capsule. Methods Volatile oil was extracted by steam distillation and the amount of extraction was taken as an index. The influence of soaking time, water addition and extraction time on the extraction process was investigated by single factor test. The inclusion of volatile oil was treated by saturated aqueous solution, Orthogonal test to study the volatile oil and β-cyclodextrin ratio, inclusion time and inclusion temperature on the inclusion process. Results The optimum extraction process was extracting with 10 times the amount of water for 6h. The optimum combination process was the ratio of volatile oil to β-cyclodextrin was 1: 8, the inclusion temperature was 30 ℃, and the inclusion time was 1h. Conclusion The optimal volatile oil extraction and inclusion process conditions are stable and feasible.