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目的：观察羟基磷灰石义眼台眼窝内植入术后血管化过程的组织病理学改变。方法：用１７只新西兰种兔分２组。Ａ组（７只）行眼球摘除眼窝内羟基磷灰石植入术；Ｂ组（１０只）行眼内容剜出自体巩膜覆盖羟基磷灰石植入术。观察２组术后第１，２，３，４，６周和第２，３，４，５，６月的大体标本形态和义眼台血管化过程中的组织病理学变化。结果：Ａ组，１周时义眼台表面孔隙内即有纤维结缔组织生长，４周时伸入义眼台中心部分孔隙内，２月后组织成熟，完全血管化；Ｂ组，术后第３周时自体巩膜与义眼台贴敷紧密，邻接的孔隙内开始有纤维结缔组织生长，２月时伸入义眼台的中心部分孔隙内，３月后组织成熟，完全血管化。结论：羟基磷灰石义眼台与眼眶组织接触面积越大其完全血管化速率越快。
Objective: To observe the histopathological changes of vascularization after hydroxyapatite orbital implantation. Methods: Seventeen New Zealand white rabbits were divided into two groups. Group A (n = 7) received ocular hydroxyapatite implantation; group B (n = 10) received ocular sclera dressing from sclera covered with hydroxyapatite. The gross specimen morphology and histopathological changes during vascularization at 1, 2, 3, 4, 6 weeks and 2, 3, 4, 5 and 6 months after operation were observed in two groups. Results: In group A, fibrous connective tissue grew in the surface pores of Yi-yuan stage at 1 week, and extended into the central part of the pores of Yi-yuan stage at 4 weeks. After 2 months, the tissues became mature and completely vascularized. In group B, When the self-sclera and Yi Yan Taiwan sticking close, adjacent to the pores began to have fibrous connective tissue growth, in February extended into the central part of the Yiyetai pores, after 3 months of tissue maturation, complete vascularization. Conclusion: The greater the contact area between hydroxyapatite and orbital tissue is, the faster the complete vascularization rate is.