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目的观察双环醇对慢性丙型病毒性肝炎的临床疗效。方法对40例慢性丙型肝炎患者随机分为治疗组、对照组各20例,治疗组予双环醇25mg口服,1d3次。对照组予维生素B、C,肝太乐等一般护肝药口服,疗程6个月。结果治疗组治疗第1、3个月末血清谷丙转氨酶(ALT)复常率高于对照组(P<0.05);治疗组患者治疗前后血清HCV-RNA对数值下降较对照组有统计学意义(P<0.05)。结论双环醇治疗慢性丙型病毒性肝炎降酶效果明显,且在人体内可能有协助抑制HCV增殖的作用。
Objective To observe the clinical effect of bicyclol on chronic hepatitis C virus. Methods Forty patients with chronic hepatitis C were randomly divided into treatment group (20 cases) and control group (20 cases). The treatment group received bicyclol 25 mg orally once daily for 3 days. The control group to vitamin B, C, liver too general and other liver medicine oral treatment for 6 months. Results The normalization rate of serum alanine aminotransferase (ALT) at the end of the first and third month of treatment in the treatment group was higher than that in the control group (P <0.05). The decrease of serum HCV-RNA in the treatment group was significantly lower than that in the control group P <0.05). Conclusion Bicyclol treatment of chronic hepatitis C has a significant effect of reducing the enzyme, and in humans may have contributed to the inhibition of HCV proliferation.