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目的探讨血清甘氨酰脯氨酸二肽氨基肽酶(GPDA)测定在血液病患者血液中的变化,对各种血液病的提示性诊断、治疗效果观察及对各种血液病的鉴别诊断中临床使用价值。方法利用测定各种血液病患者血清中GPDA活性的变化,分析比较GPDA测定在血液病中的临床价值。结果发现GPDA酶活性在健康者与各种血液疾病之间的差异具有显著性;在髓系急性白血病中,未缓解者与缓解者之间差异具有显著性;在急性淋巴细胞性白血病中,未缓解者与缓解者之间差异具有极显著性;其他液病之间差异无显著性。GPDA测定对血液病辅助诊断、白血病的疗效观察中具有一定的价值,而对各种血液病的鉴别诊断没有价值。
Objective To investigate the changes of serum glycyl-proline dipeptidyl aminopeptidase (GPDA) in the blood of patients with hematological diseases, and to provide suggestive diagnosis and treatment of various blood diseases and the differential diagnosis of various blood diseases Clinical use value. Methods The determination of serum GPDA activity in patients with various blood diseases changes, analysis and comparison of GPDA determination in the blood disease clinical value. The results showed that the activity of GPDA was significantly different between healthy subjects and all kinds of hematological diseases. In myeloid acute leukemia, the difference between undiagnosed and relieved persons was significant. In acute lymphoblastic leukemia, The difference between the reliever and the reliever was extremely significant; there was no significant difference between other fluids. GPDA determination of hemophilia-assisted diagnosis, the efficacy of leukemia in the observation has a certain value, but the differential diagnosis of various blood diseases is of no value.