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Direct chemoselective oxidation of 8-1actones via highly stable benzyl radical cyclization is reported.The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl- 1-naphthoic acid in the presence of K_2S_2O_8-CuCl_2 results to theδ-1actones in moderate to good yields.The advantages of this methodology is using water as a solvent and utilizing available starting materials.
Direct chemoselective oxidation of 8-1actones via highly stable benzyl radical cyclization is reported. The one-pot conversion of premade substituted 5-aryl pentanoic acid and 8-benzyl- 1-naphthoic acid in the presence of K 2 S 2 O 8-CuCl 2 results to the delta-1 actones in moderate to good yields.The advantages of this methodology is using water as a solvent and utilizing available starting materials.