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DDPH 3～10 mg/kg iv降低DOCA—盐型及自发性高血压(SH)大鼠的MAP及HR;50,100mg/kg ig降低清醒正常血压及SH大鼠MAP及HR·心率减慢较降压作用持续时间短。DDPH(10,100μmol/L)对犬乳头状肌收缩力及静息30 s后第一次收缩(PRC_(30))有抑制作用。小鼠ig DDPH的LD_(50)为640 mg/kg,95％可信限为567～713mg/kg。麻醉大鼠静脉恒速灌注DDPH的致死量为47±SD 4 mg/kg。表明DDPH对实验性高血压大鼠有降压作用,并对心肌收缩力及肌浆网Ca~(2+)的释放有轻度抑制作用。
DDPH 3 ~ 10 mg / kg iv reduced the MAP and HR in DOCA-salt and spontaneously hypertensive (SH) rats; 50 and 100 mg / kg ig decreased the normal blood pressure and MAP and HR · decreased heart rate in SH rats Short duration of compression. DDPH (10,100μmol / L) inhibited the contractility of canine papillary muscle and the first contraction (PRC_ (30)) after resting 30 s. The LD50 of mouse ig DDPH was 640 mg / kg and the 95% confidence limit was 567-713 mg / kg. The lethal dose of intravenous infusion of DDPH in anesthetized rats was 47 ± SD 4 mg / kg. DDPH showed antihypertensive effect on experimental hypertensive rats, and mild inhibition of myocardial contractility and sarcoplasmic reticulum Ca ~ (2+) release.