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目的 观察小白鼠经口腔和胃服用精制α型人白细胞干扰素的吸收情况。方法小鼠经口腔和 胃服用干扰素后，分别用微量细胞病变抑制法和ＥＬＩＳＡ检测小鼠血清中的干扰素活性。结果 含服干扰素的小鼠 血清用两种方法均可检出干扰素活性，且可被α型干扰素抗体完全中和；经胃服用干扰素的小鼠血清中未检出干 扰素。结论 含服是干扰素吸收的重要途径。
Objective To observe the absorption of refined α-type human leukocyte interferon (IFN-α) by oral and gastric administration in mice. Methods Mice were treated with interferon in the oral cavity and stomach, and the activity of interferon in the serum of the mice was detected by ELISA. Results Interferon-containing mouse sera detected interferon activity by both methods and were completely neutralized by the interferon alpha interferon. Interferon was not detected in the sera from mice given stomach. Conclusion Inclusion is an important way of interferon absorption.