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目的观察尼可地尔联合地尔硫治疗心肌桥的临床疗效。方法将经冠脉造影明确诊断心肌桥的98例患者随机分为治疗组和对照组49例,对照组应用β受体阻滞剂进行治疗,治疗组应用尼可地尔联合地尔硫进行治疗,并对治疗效果进行了比较分析。结果治疗后2组患者ST段压低次数、持续时间均明显下降(P<0.01),心肌缺血总负荷明显改善(P<0.01),体力负荷持续时间、心肌缺血功率显著增加(P<0.01),总缺血负荷显著降低(P<0.01),且上述各指标治疗组均优于对照组(P<0.01)。结论尼可地尔联合地尔硫治疗心肌桥效果明显,值得临床推广应用。
Objective To observe the clinical efficacy of nicorandil combined with diltiazem in the treatment of myocardial bridge. Methods A total of 98 patients with myocardial bridge diagnosed by coronary angiography were randomly divided into treatment group (49 cases) and control group (42 cases). Patients in the control group were treated with β-blocker. Nicorandil combined with diltiazem Treatment, and the comparative analysis of the treatment effect. Results After treatment, the number of ST segment depression and duration were significantly decreased (P <0.01), the total myocardial ischemia load was significantly improved (P <0.01), the duration of physical load and the myocardial ischemia power were significantly increased (P <0.01 ), The total ischemic load was significantly lower (P <0.01), and the above indicators of the treatment group were better than the control group (P <0.01). Conclusion Nicorandil combined with diltiazem treatment of myocardial bridge effect is obvious, worthy of clinical application.