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骨髓间充质干细胞(mesenchymal stem cells,MSCs)是来源于骨髓基质的一类具有高度自我更新能力和多向分化潜能的成体干细胞.因其具有容易获取、体外扩增方便迅速、移植排斥反应较弱等优点而成为临床应用的理想细胞模型.骨髓间充质干细胞向成肌和成脂的分化对动物机体内肌肉和脂肪的组成具有直接影响,因而与肉品质及人类健康息息相关.本文综述了骨髓间充质干细胞定向分化为骨骼肌细胞和脂肪细胞的过程及其调控机制,并重点分析了关键调控因子PRDM16(PR domain-containing16)和骨形态发生蛋白(bone morphogenetic proteins,BMPs)在骨髓间充质干细胞成肌和成脂分化中的作用.
Mesenchymal stem cells (MSCs) are a group of adult stem cells derived from bone marrow stroma, which have a high degree of self-renewal ability and multi-directional differentiation potential. Because of their easy availability and rapid expansion in vitro, Weakness and other advantages and become the ideal cell model for clinical applications.Differentiation of mesenchymal stem cells into myogenic and adipogenic have a direct impact on the composition of muscle and fat in the body of the animal and therefore are closely related to the quality of meat and human health.This article reviews Bone Marrow Mesenchymal Stem Cells Differentiate Into Skeletal Muscle Cells And Adipocytes And Its Regulatory Mechanisms, And The Key Regulatory Factors Of Prdm16 (PR domain-containing16) And Bone Morphogenetic Proteins (BMPs) In Bone Marrow The role of mesenchymal stem cells in myogenic and adipogenic differentiation.