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目的了解该地区人乳头瘤病毒(HPV)亚型感染状况,为临床宫颈疾病早期筛查及预防提供指导依据。方法对2011年1月-2013年6月在该院妇科门诊就诊的4 995例女性进行宫颈脱落细胞基因芯片HPV亚型检测。结果 HPV总感染率为36.50%,高危型HPV感染率为29.09%,占HPV感染人群的79.70%;低危型HPV感染率为3.38%,高低危型混合感染率为4.02%。单一亚型HPV感染率为24.8%(1 239/4 995),多重HPV感染率为11.69%(584/4 995)。HPV感染人群检出率最高的5种高危亚型为HPV 16、58、52、18、33,检出率依次为24.39%(647/2 653)、11.19%(297/2 653)、11.19%(297/2 653)、7.65%(203/2 653)和5.43%(144/2 653),占高危型感染人群的69.96%(1 588/2 270)。低危型中3种主要的检出亚型为HPV 11、HPV 6、CP8304。HPV感染在<25岁及≥45岁两个年龄段女性呈双峰分布,不同年龄段女性HPV感染率比较,差异有统计学意义(P<0.001)。结论山西省高危型HPV感染以HPV 16、58、52、18、33亚型多见,在<25岁及≥45岁两个年龄段女性HPV感染高发。
Objective To understand the subtype infection of human papillomavirus (HPV) in this area and provide guidance for the early screening and prevention of clinical cervical diseases. Methods A total of 4995 women with gynecological outpatients in our hospital from January 2011 to June 2013 were enrolled in this study. Results The total HPV infection rate was 36.50%, the high-risk HPV infection rate was 29.09%, accounting for 79.70% of the HPV-infected population; the low-risk HPV infection rate was 3.38% and the high-low-risk type infection rate was 4.02%. The prevalence of HPV in a single subtype was 24.8% (1239/4995), and the multiple HPV infection rate was 11.69% (584/4995). The five high-risk subtypes with the highest detection rate of HPV infection were HPV 16,58,52,18,33 and the detection rates were 24.39% (647/2653), 11.19% (297/2653), 11.19% (297/2 653), 7.65% (203/2 653) and 5.43% (144/2 653) respectively, accounting for 69.96% (1558/2 270) of the high-risk infected population. The three major subtypes detected in low-risk type are HPV 11, HPV 6 and CP8304. HPV infection showed a bimodal distribution in women aged <25 years and ≥45 years. There was a statistically significant difference in HPV infection rates among women of different ages (P <0.001). Conclusion High-risk HPV infection in Shanxi Province is more common in HPV 16, 58, 52, 18 and 33 subtypes. HPV infection is common in women aged <25 years and ≥45 years.