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肺癌是癌症相关死亡的主要原因，其发病率和死亡率均位居前列，严重影响患者的生存时间和生命质量。开发新的肿瘤细胞作用靶点，扩大肺癌患者的受益人群成为近年来研究的热点和难点。RNA结合蛋白人类抗原R（HuR）在肺癌的发生、发展中发挥着重要作用，可以通过与肺癌细胞中特定的mRNA结合，影响肺癌细胞多种基因、蛋白、分子的转录、翻译和合成等多个步骤，促进肺癌细胞的增殖、分化和凋亡等多种生物学功能，在肺癌的分子诊断、治疗及预后具有重要意义。文章将根据国内外相关文献，对HuR的生物学特性及其在肺癌中与之相关的调控因子的相互作用研究进展进行综述。“,”Lung cancer is the main cause of cancer-related deaths, and its morbidity and mortality is the highest, which seriously affects patients\' survival time and quality of life. To develop new targets of tumor cells and expand the beneficiary population of lung cancer patients have become a hot and difficult research topic in recent years. RNA binding protein human antigen R (HuR) plays an important role in the development and progression of lung cancer. It can affect the transcription, translation and synthesis of multiple genes, proteins and molecules of lung cancer cells by binding to specific mRNA in lung cancer cells, and promote proliferation, differentiation and apoptosis of lung cancer cells. HuR is of great significance in molecular diagnosis, treatment and prognosis of lung cancer. This article will review the biological characteristics of HuR and research progress of its interaction with HuR-related regulatory factors in lung cancer based on relevant domestic and foreign literatures.