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目的研究静脉补充铁剂对早产儿铁储存状况的改善程度。方法将需要肠外营养(PN)的早产儿56例随机分为对照(不含铁)组、含铁1组(蔗糖铁100μg·kg-1·d-1)、含铁2组(蔗糖铁200μg.kg-1.d-1)3组。每组PN应用时间14 d。铁剂加入PN中慢速输注。每例入选早产儿在PN前后分别检测铁储存指标[铁蛋白(SF),血清铁(SI),总铁结合力(TIBC)、转铁蛋白饱和度(TS)],统计分析组内及组间是否有差异,探讨静脉补充铁剂是否对早产儿铁储存有影响。结果与干预前比较,含铁2组SI、SF和TS显著升高,TIBC显著降低(均P<0.01);而含铁1组和对照组除TS显著升高(均P<0.01)外,其余各项指标的差异均无统计学意义(均P>0.05)。3组间比较,干预后除TIBC含铁2组显著低于对照组(P<0.01)外,其余各项指标3组间的差异均无统计学意义(均P>0.05)。结论含铁200μg·kg-1·d-1的PN可改善早产儿的铁储存指标。
Objective To study the effect of intravenous iron supplementation on iron storage in preterm infants. Methods 56 cases of preterm infants who needed parenteral nutrition (PN) were randomly divided into control (non-iron) group, iron group 1 (100μg · kg-1 · d-1 sucrose), iron group 2 200 μg.kg-1.d-1) 3 groups. Each group of PN application time 14 d. Slow-infusion of iron into PN. The iron storage indexes (SF, SI, TIBC, TS) of preterm infants were detected before and after PN, Whether there is a difference between, to explore whether intravenous iron supplementation has an effect on iron storage in preterm children. Results Compared with those before intervention, SI, SF and TS were significantly increased and TIBC was significantly decreased in the iron-containing group (all P <0.01); while iron-containing group 1 and control group were significantly higher than those in the control group (all P <0.01) The remaining indicators were no significant difference (all P> 0.05). There were no significant differences among the three groups except intervention group (P <0.01), except TIBC ferrous group (P> 0.05). Conclusions PN with 200 μg · kg-1 · d-1 iron can improve iron storage in preterm infants.