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目的探讨氨氯地平联合贝那普利应用于高血压脑卒中预防的效果。方法选取患有高血压脑卒中患者86例,随机分为观察组和对照组,观察组采用氨氯地平联合贝那普利同时进行治疗,给药量为7mg/d,1次/d;对照组使用同样的氨氯地平,给药方案改为2 mg/d,1次/d,治疗时间为2个月。结果通过两个月的不同给药方案后,观察组和对照组的舒张压与收缩压差异具有统计学意义,P<0.05;且可以看出观察组降低幅度大于对照组;观察组有5例患者复发高血压性脑卒中,占总体11.6%,而对照组发生高血压性脑卒中的病例数为11例,占总体比例为25.6%。结果显示观察组的发病率低于对照组,两组比较差异具有统计学意义,P<0.05。结论高血压脑卒中采用氨氯地平联合贝那普利治疗疗效较好。
Objective To investigate the effect of amlodipine combined with benazepril in the prevention of hypertension stroke. Methods Totally 86 hypertensive stroke patients were randomly divided into observation group and control group. The observation group was treated with amlodipine combined with benazepril at the same time, the dosage was 7mg / d, once / d. Group using the same amlodipine, dosing regimen changed to 2 mg / d, 1 / d, treatment time was 2 months. Results After two months of different dosing regimen, the difference between diastolic blood pressure and systolic blood pressure in the observation group and the control group was statistically significant (P <0.05), and the decrease in the observation group was larger than that in the control group. In the observation group, there were 5 cases Hypertensive stroke recurred in 11.6% of the patients, compared with 11 cases of hypertensive stroke in the control group, accounting for 25.6% of the total. The results showed that the incidence of observation group was lower than the control group, the difference between the two groups was statistically significant, P <0.05. Conclusion Amlodipine combined with benazepril in hypertensive stroke patients is effective.