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目的通过检测VEGF-C、NF-κBp65及Survivin在鼻咽癌组织(实验组)及鼻咽部慢性炎症组织(对照组)中的表达,探讨它们在鼻咽癌发生、发展过程中的作用及相互关系。方法采用免疫组织化学技术SP法检测VEGF-C、NF-κBp65及Survivin在57例鼻咽癌和20例对照组中的表达情况,并观察其与鼻咽癌的临床病理特征的关系。结果VEGF-C、NF-κBp65及Survivin在鼻咽癌组织的阳性表达率分别为73.68%、61.40%、68.42%,而在对照组中的表达率分别为40.00%、30.00%、20.00%,两者差异有统计学意义(P<0.05)。VEGF-C、NF-κBp65及Survivin的表达与临床分期、淋巴结转移密切相关(P<0.05)。NF-κBp65的表达与VEGF-C及Survivin的表达呈显著正相关,VEGF-C与Survivin的表达亦呈显著正相关。结论NF-κBp65可能通过上调VEGF-C及Survivin的表达促进鼻咽癌的发生、发展及颈部淋巴结转移;VEGF-C和Survivin在鼻咽癌的发生发展中存在着协同作用。
Objective To investigate the expression of VEGF-C, NF-κBp65 and Survivin in nasopharyngeal carcinoma (NPC) and chronic inflammation of nasopharyngeal tissues (NPC) and their roles in the development and progression of NPC Interrelationship. Methods The expression of VEGF-C, NF-κBp65 and Survivin in 57 cases of nasopharyngeal carcinoma and 20 cases of control group were detected by SP immunohistochemistry. The relationship between VEGF-C, NF-κBp65 and clinicopathological features was observed. Results The positive rates of VEGF-C, NF-κBp65 and Survivin in nasopharyngeal carcinoma were 73.68%, 61.40% and 68.42%, respectively, while those in the control group were 40.00%, 30.00% and 20.00% The difference was statistically significant (P <0.05). The expression of VEGF-C, NF-κBp65 and Survivin were closely related to clinical stage and lymph node metastasis (P <0.05). The expression of NF-κBp65 was positively correlated with the expression of VEGF-C and Survivin, and the expression of VEGF-C and Survivin was also positively correlated. Conclusion NF-κBp65 may promote the occurrence and development of nasopharyngeal carcinoma and cervical lymph node metastasis by up-regulating the expression of VEGF-C and Survivin. Synergistic effect exists between VEGF-C and Survivin in the occurrence and development of nasopharyngeal carcinoma.