论文部分内容阅读
维甲酸相关孤儿受体属于类固醇激素受体超家族；在机体免疫系统的分化成熟中至关重要，其在次级淋巴组织发育、T淋巴细胞分化成熟及 T 细胞的谱系分化过程中均起重要作用。近年来，人们通过深入研究进一步阐明了该受体为配体依赖的转录因子；并揭示了其在一些疾病过程中的作用，包括自身免疫病及肿瘤。该文对其相关研究进行综述。“,”Retinoid-related orphan receptors are transcription factors belonging to the steroid hormone receptor superfamily; they play critical roles in immune system,as revealed in several studies that they are essential for the development of lymphoid tissues,differentiation and maturation of T lymphocytes and T cell lineage specification.Recent reports confirmed the receptors are ligand dependent transcription factors and revealed their roles in some diseases,including several autoimmune diseases and tumors.Here is to make a review of the preceding aspects of the receptors.