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目的 :观察兰索拉唑联合西沙必利与雷尼替丁联合西沙必利治疗反流性食管炎的疗效比较。方法 :将反流性食管炎病人 10 8例分为治疗组 6 0例 ,用兰索拉唑 (30mg口服 ,qN 9:0 0 )加西沙必利 10mg(口服 ,4次 /d) ;对照组 4 8例用雷尼替丁 (150mg口服 ,2次 /d)加西沙必利 (10mg口服 ,4次 /d)。疗程均为 4周。结果 :内镜复查治疗组原食道管粘膜病损愈合、好转的总效率为97% ,对照组为 6 2 % ;治疗组胃灼热和反流症状 ,总有效率分别达 93%和 92 % ,而对照组为 6 2 %和6 2 % (均P <0 .0 5)。结论 :兰索拉唑联合西沙必利较雷尼替丁联合西沙必利治疗反流性食管炎效果好。
Objective: To observe the efficacy of lansoprazole combined with cisapride and ranitidine plus cisapride in the treatment of reflux esophagitis. Methods: A total of 108 patients with reflux esophagitis were divided into treatment group (60 cases) and lansoprazole (30 mg orally, qN 9: 0 0) plus cisapride 10 mg (oral, 4 times daily) Group 48 patients with ranitidine (150mg orally, 2 times / d) plus cisapride (10mg orally, 4 times / d). The course of treatment is 4 weeks. Results: The total effective rate was 97% in the treatment group and 62% in the control group. The total effective rate of heartburn and reflux was 93% and 92% respectively in the treatment group, While the control group was 62% and 62% (all P <0.05). Conclusion: Lansoprazole combined with cisapride than ranitidine combined with cisapride in the treatment of reflux esophagitis effective.