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目的观察在腹腔镜子宫肌瘤剔除术(laparoscopic hysteromyomectomy,LM)中使用卡前列素氨丁三醇的效果,评估其在LM中的应用价值。方法将60例子宫肌瘤患者分为两组,观察组30例在术前30min肌肉注射卡前列素氨丁三醇250μg,对照组30例在术中同时给予缩宫素(Oxytocin,OT)20U静脉维持滴注,比较两组患者术中出血量、手术时间、术中不良反应发生率、术后24h基本情况的差异。结果观察组术中平均出血量明显减少,手术时间明显缩短(P<0.05)。两组患者术中不良反应发生率、术后24h基本情况比较差异无统计学意义(P>0.05)。结论与术中应用OT相比,LM前应用卡前列素氨丁三醇,在减少术中出血、缩短手术时间方面具有明显优势。
Objective To observe the effect of carboprost trometamol in laparoscopic hysteromyomectomy (LM) and to evaluate its value in LM. Methods Sixty patients with uterine fibroids were divided into two groups. 30 patients in the observation group were given carboprost trometamol 250 μg intramuscularly 30 min before operation and 30 patients in the control group were given intraoperative oxytetracycline (OT) 20 U Intravenous maintenance infusion, the two groups were compared intraoperative blood loss, operation time, the incidence of adverse reactions during surgery, 24h after the basic situation differences. Results The average amount of bleeding in the observation group was significantly reduced, the operation time was significantly shorter (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups during the 24 hours after operation (P> 0.05). Conclusions Compared with intraoperative use of OT, the application of carboprost tromethamine before LM has obvious advantages in reducing intraoperative bleeding and shortening the operation time.