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目的:探讨孕酮,CA125及TNF-α水平与先兆流产发生的关系。方法:选择2014年2月-2015年2月在我院诊断并接受治疗的先兆流产患者60例,根据妊娠结局不同,将患者分为完成妊娠组和终止妊娠组。另选取同期顺利分娩的产妇作为对照组。比较三组研究对象血清孕酮,CA125及TNF-α水平。结果:先兆流产患者血清孕酮水平低于对照组,而CA125及TNF-α水平高于对照组,差异具有统计学意义(P<0.05);先兆流产终止妊娠组血清孕酮水平低于完成妊娠组,而CA125及TNF-α水平高于完成妊娠组,差异具有统计学意义(P<0.05)。孕酮,CA125及TNF-α水平是先兆流产发生的影响因素(P<0.05)。结论:孕酮水平低,CA125及TNF-α水平高是先兆流产发生的危险因素。临床应给予高度重视,积极采取有效的保胎治疗,避免不良妊娠结局。
Objective: To investigate the relationship between progesterone, CA125 and TNF-α levels and threatened abortion. Methods: Sixty patients with threatened abortion diagnosed and treated in our hospital from February 2014 to February 2015 were selected. According to different pregnancy outcomes, the patients were divided into the completion pregnancy group and the termination pregnancy group. Another choose the same period of successful delivery of maternal as a control group. The levels of serum progesterone, CA125 and TNF-α in three groups were compared. Results: The levels of serum progesterone in threatened abortion patients were lower than those in control group, while the levels of CA125 and TNF-α were higher than those in control group (P <0.05). Serum progesterone level in threatened abortion termination group was lower than that in completion of pregnancy Group, while the levels of CA125 and TNF-αwere higher than that of pregnancy group, the difference was statistically significant (P <0.05). Progesterone, CA125 and TNF-α levels were the influencing factors of threatened abortion (P <0.05). Conclusion: Low progesterone levels and high CA125 and TNF-α levels are risk factors for threatened abortion. Clinical should be given high priority, and actively take effective miscarriage treatment to avoid adverse pregnancy outcomes.