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研究了β－胡萝卜素对体外巨噬细胞（Ｍφ）抗肿瘤功能的调节作用。结果表明，巨噬细胞的细胞毒作用与其活化程度、靶细胞敏感性、效／靶比值（Ｅ／Ｔ）有关；１０~（－６）ｍｏｌ／Ｌβ－胡萝卜素对巯基乙醇酸钠培养基诱导的巨噬细胞（Ｔ．Ｇ－Ｍφ）细胞毒阻滞效应无显著作用，但显著提高脂多糖（ＬＰＳ）活化的Ｔ．Ｇ－Ｍφ的细胞毒作用，而１０~（－６）ｍｏｌ／Ｌβ－胡萝卜素与ＬＰＳ联合应用则可显著增加ＴＮＦ、ＩＬ－１的产生。提示β－胡萝卜素可通过增加Ｍφ淋巴因子的产生，促进Ｍφ的抗肿瘤活性。
The effect of β-carotene on the anti-tumor function of macrophage (Mφ) in vitro was studied. The results showed that the cytotoxicity of macrophages was related to the degree of activation, target cell sensitivity and E / T ratio. The induction of thioglycollate medium with 10 -6 mol / L β-carotene (T.G-Mφ) did not show significant cytotoxic effect, but significantly increased lipopolysaccharide (LPS) -activated T. G-Mφ, while the combination of 10 -6 mol / L β-carotene and LPS significantly increased the production of TNF and IL-1. It is suggested that β-carotene can promote the anti-tumor activity of Mφ by increasing the production of Mφ lymphokines.