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用光镜观察致癌剂二甲基苯并蒽（ＤＭＢＡ）诱发８９只金黄地鼠颊囊在不同时期的癌变过程，其结果显示：在连续涂布０．５％ＤＭＢＡ３周后即出现轻度上皮异常增生，连续涂布５周即出现中度异常增生，６周至９周均出现重度异常增生甚至原位癌。提示０．５％ＤＭＢＡ诱发金黄地鼠颊囊出现异常增生的最初时间为第３周，６周后即已发展至原位癌，也进一步提示１～３周是研究金黄地鼠颊囊出现上皮异常增生的最初阶段
Light microscope was used to observe the carcinogenesis of 89 golden hamster cheek pouches induced by the carcinogen dimethylbenzopyrene (DMBA). The results showed that mild epithelial cells appeared after continuous application of 0.5% DMBA for 3 weeks. Abnormal hyperplasia, moderately abnormal hyperplasia occurred 5 weeks after continuous application, and severe dysplasia or carcinoma in situ appeared from 6 weeks to 9 weeks. It is suggested that 0.5% DMBA induces abnormal proliferation of golden hamster cheek pouch at the beginning of the 3rd week, and it has developed to carcinoma in situ after 6 weeks. It further suggests that 1 to 3 weeks is the study of the epithelium of the golden hamster cheek pouch. The initial stage of abnormal hyperplasia