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目的:观察沙利度胺对复发性阿弗他溃疡(RAU)患者外周血淋巴细胞亚群的影响及治疗疗效。方法:选择轻型RAU患者(轻型RAU组)85例,健康对照组80例,随访观察服用沙利度胺25 mg/d治疗轻型RAU的疗效;同时比较健康对照组,轻型RAU组治疗前后外周血淋巴细胞亚群检测结果。结果:和健康对照组相比,轻型RAU患者CD4+T淋巴细胞数目减少,CD8+T淋巴细胞增多,淋巴细胞亚群比例失调;经沙利度胺治疗后,轻型RAU患者淋巴细胞亚群比例异常改善,同时患者溃疡间歇期明显延长,溃疡数目明显减少,差异均具有统计学意义(P<0.05)。结论:轻型RAU患者存在外周血T淋巴细胞亚群比例异常,沙利度胺可有效调节CD4~+、CD8~+T淋巴细胞亚群比例,延长溃疡间歇期,减少溃疡发作,临床疗效满意。
Objective: To observe the effect of thalidomide on peripheral blood lymphocyte subsets in patients with recurrent aphthous ulcer (RAU) and its curative effect. Methods: Eighty-five patients with mild RAU (mild RAU group) and 80 healthy volunteers (control group) were enrolled in this study. The follow-up was performed to evaluate the efficacy of thalidomide 25 mg / d in the treatment of RAU. Lymphocyte subsets test results. Results: Compared with healthy control group, the number of CD4 + T lymphocytes, CD8 + T lymphocytes and lymphocyte subsets were decreased in patients with mild RAU. After thalidomide treatment, the proportion of lymphocyte subsets Abnormal improvement, at the same time the patient’s ulcer interval was significantly prolonged, the number of ulcers was significantly reduced, the difference was statistically significant (P <0.05). CONCLUSIONS: There is an abnormal proportion of peripheral T lymphocyte subsets in patients with mild RAU. Thalidomide can effectively regulate the proportion of CD4 ~ + and CD8 ~ + T lymphocyte subsets, prolong the interval of ulcer and reduce the ulcer attack. The clinical efficacy is satisfactory.