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环境污染物多环芳烃(PAH)进入机体细胞后,必将经细胞内毒物代谢酶系统催化代谢活化和灭活。首先和关键性的代谢步骤是经内质网膜上的混合功能氧化酶系(MFO)催化发生环氧化或羟化。混合功能氧化酶是一个复杂的多成分酶系统,主要是由NADPH-细胞色素P-460还原酶、细胞色素P-450和磷脂组成。早已发现多种有机
Environmental pollutants Polycyclic aromatic hydrocarbons (PAH) into the body cells, the metabolic pathway must be activated by the catalytic system and drug inactivation. The first and key metabolic step is the epoxidation or hydroxylation catalyzed by mixed-function oxidase (MFO) on the endoplasmic reticulum. Mixed-function oxidase is a complex multi-component enzyme system consisting mainly of NADPH-cytochrome P-460 reductase, cytochrome P-450 and phospholipid. Already found a variety of organic