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目的:探讨穿心莲内酯磺酸盐(喜炎平)佐治儿童急性病毒性下呼吸道感染的疗效。方法:选择2008年1月～2010年12月在我院儿科住院的急性下呼吸道感染患儿120例(病原学检查为病毒感染),随机分为两组。对照组给予止咳化痰、平喘等常规治疗,治疗组在常规治疗基础上加用穿心莲内酯磺酸盐注射液0.2～0.4 mL/(kg.d),对照组在常规治疗基础上加用利巴韦林注射液10 mg/(kg.d),均用5%葡萄糖注射液稀释后静脉滴注,1次/d,连用7 d。结果:治疗组总有效率93.3%,对照组总有效率75.0%,两组总有效率比较差异有统计学意义(χ2=7.57,P<0.01)。治疗组在退热时间、气喘改善时间、咳嗽消失时间、肺部体征消失时间、胸部X线恢复正常时间及住院天数等方面均短于对照组,差异有统计学意义(P<0.01)。结论:穿心莲内酯磺酸盐注射液佐治儿童急性病毒性下呼吸道感染疗效显著。
Objective: To investigate the efficacy of andrographolide sulphonate (Xiyanping) in children with acute viral lower respiratory tract infection. Methods: From January 2008 to December 2010 in our hospital pediatric acute lower respiratory tract infection in 120 children (etiological examination for viral infection), were randomly divided into two groups. The control group was given conventional therapy such as relieving cough and reducing phlegm and relieving asthma. The treatment group was given 0.2 ~ 0.4 mL / (kg · d) of andrographolide sulfonate injection on the basis of routine treatment, while the control group was added on the basis of routine treatment Ribavirin injection 10 mg / (kg.d), were diluted with 5% glucose injection after intravenous drip, 1 / d, once every 7 d. Results: The total effective rate was 93.3% in the treatment group and 75.0% in the control group. The total effective rate in the two groups was statistically significant (χ2 = 7.57, P <0.01). The treatment group was shorter than the control group in the aspects of antipyretic time, improvement time of asthma, disappearance of cough, disappearance of lung signs, normal time of chest X-ray recovery and days of hospitalization, the difference was statistically significant (P <0.01). CONCLUSION: Andrographolide sulfonate is effective in treating children with acute viral lower respiratory tract infection.