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目的分析黏膜相关淋巴瘤(MALT)的临床特点和疗效,为改进其诊断及治疗提供依据。方法对我院收治的15例临床资料进行回顾性的总结和分析。结果 15例MALT淋巴瘤患者发病年龄为18～84岁(中位年龄63岁).其中被诊断为Ⅰ期7例,Ⅱ期7例,Ⅳ期1例。原发部位包括胃肠道4例,鼻咽部4例,乳腺2例,皮肤、腮腺,颞窝软组织、扁桃体和宫颈部各1例。大多以手术切除局部肿物,后接受系统的化疗,有的辅以局部的放射治疗。结论黏膜相关淋巴组织淋巴瘤多发生于老年患者,呈惰性生长,临床进展缓慢,早期病变对放化疗大多敏感,化疗后加用放疗有可能改善局部控制。不同的发病部位与临床分期,分类,对治疗方案的选择有较重要的意义。
Objective To analyze the clinical features and curative effect of mucosa-associated lymphoma (MALT) and provide the basis for improving its diagnosis and treatment. Methods 15 cases of clinical data admitted to our hospital were retrospectively summarized and analyzed. Results The onset age of 15 patients with MALT lymphoma was 18-84 years old (median age 63 years), of whom 7 were diagnosed as stage Ⅰ, 7 as stage Ⅱ and 1 as stage Ⅳ. The primary sites included 4 cases of gastrointestinal tract, 4 cases of nasopharynx, 2 cases of breast, 1 case of skin, parotid gland, soft tissue of temporal fossa, tonsil and cervix. Most of the surgical removal of local tumor, after receiving systemic chemotherapy, and some supplemented by local radiation therapy. Conclusions Mucosa-associated lymphoid tissue lymphoma mostly occurs in elderly patients and develops in an inert manner. The clinical progress is slow. Early lesions are mostly sensitive to chemoradiotherapy and chemotherapy. Radiotherapy after chemotherapy may improve local control. Different parts of the disease and clinical stage, classification, the choice of treatment programs have more significance.