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为评价胰岛素抵抗对持续病毒学应答的影响,从接受聚乙二醇干扰素和利巴韦林联合治疗的HIV/HCV合并感染者中选择155名研究对象进行多中心队列研究,主要的结果变量是持续病毒学应答。研究结果显示:55名患者获得持续病毒学应答,其中42名胰岛素抵抗指数小于4的患者获得持续病毒学应答,13名HOMA>4的患者获得持续病毒学应答,但无统计学差异(P=0.27)。对基因1型和4型感染者分析结果显示:HOMA<4和>4的患者的持续病毒学应答无统计学差异(P=0.8)。多变量分析结果显示:基因3型、基线HCV病毒载量和基线LDL胆固醇水平能够影响HIV/HCV合并感染者的持续病毒学应答,而胰岛素抵抗对持续病毒学应答无影响。
To assess the impact of insulin resistance on sustained virologic response, 155 cohorts of 155 HIV / HCV co-infected patients treated with peginterferon and ribavirin were enrolled in a multicenter cohort study. The primary outcome variables It is a sustained virological response. The results showed that: 55 patients received a sustained virological response, of which 42 patients with insulin resistance index of less than 4 to obtain a sustained virological response, 13 patients with HOMA> 4 sustained virologic response, but no significant difference (P = 0.27). Analysis of patients with genotypes 1 and 4 showed no significant difference in sustained virologic response among patients with HOMA <4 and> 4 (P = 0.8). Multivariate analysis showed that genotype 3, baseline HCV viral load, and baseline LDL cholesterol levels could affect the sustained virologic response in HIV / HCV co-infected patients, whereas insulin resistance had no effect on sustained virologic response.