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本文以人体外周血淋巴细胞微核率(MF)为指标,探讨了高原环境能否引起正常人体细胞染色体损伤及其损伤的规律性。结果显示:进入4000m海拔地区一个月前后的MF没有显著变化(p>0.05),移居4080m高原5年以上的三组人体MF随着移居年限的增加而增加,比平原人体MF显著增加(p<0.01,p<0.001),海拔4080m高原的世居人体MF和平原相比无显著性差异(p>0.05)。结果表明高原环境对长期生活在高原的移居人体的染色体有一定的损伤作用。本文最后还对高原环境引起人体染色体损伤的机理进行了详细的讨论。
In this paper, human peripheral blood lymphocytes micronucleus rate (MF) as an indicator to explore the high-altitude environment can cause normal human chromosome damage and regularity. The results showed that there was no significant change in the MF at 4000m altitude (p> 0.05). The MFs of three groups that migrated to the plateau of 4080m for more than 5 years increased with the increase of immigration years and significantly increased (P < 0.01, p <0.001). There was no significant difference in the MF of native population at 4080 m altitude (p> 0.05). The results show that the plateau environment has some damage to the chromosomes of migrants living on the plateau for a long time. Finally, this paper also discussed in detail the mechanism of human chromosome damage caused by plateau environment.