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目的:研究排脓散的抗炎作用和复方配伍的定量规律。方法:用正交设计法安排实验,选择醋酸致小鼠腹腔毛细血管通透性亢进为急性炎症模型,以阿司匹林和生理盐水为对照,以血管通透性大小作为炎症指标,定量分析各药味的抗炎作用和相互作用。结果:排脓散及其拆方均不同程度的抑制炎症的渗出,具有抗炎作用。最大效应组合是排脓散全方,与阳性对照药比较无显著性差异(P>0.05),组方的预测效应区间为0.067~0.161(OD值)。全方配伍相互作用分析为拮抗作用,各组分按重要程度排序依次是枳实、白芍、桔梗。结论:排脓散全方对醋酸所致小鼠腹腔毛细血管通透性亢进具有抑制作用,枳实药效作用最强,但药味间呈现拮抗。
Objective: To study the anti-inflammation effect and the quantitative regularity of the compound compatibility of Paishu San. METHODS: The experiment was arranged by orthogonal design, and the acetic acid-induced hyperpermeability in mice was selected as the model of acute inflammation. Aspirin and saline were used as controls, and the vascular permeability was used as an index of inflammation to quantitatively analyze the odor of each drug. Anti-inflammatory effects and interactions. Results: The excretion of purulent granules and its disassembled prescriptions all inhibited the exudation of inflammation in different degrees, and had anti-inflammatory effects. The maximal effect combination was total discharge, and there was no significant difference compared with the positive control drug (P>0.05), and the prediction effect interval of the prescription was 0.067-0.161 (OD value). All interactions were antagonistic to the interaction analysis, and the order of the components was in order of importance, ie, citrus aurantium, white peony, and campanulaceae. Conclusion: Paishun Sanfang has inhibitory effect on acetic acid-induced hyperpermeability of capillary in the abdominal cavity of mice, and it has the strongest pharmacological effect, but exhibits antagonistic effects.