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目的通过检测胎盘部位血管生长抑素(AS)、血管内皮生长因子(VEGF)的表达,探讨与子痫前期发病的关系。方法选择30例健康产妇为对照组,54例子痫前期患者为患者组,采用免疫组织化学方法检测AS、VEGF在胎盘部位的表达。结果子痫前期组胎盘AS表达强度与对照组比较显著增强(P<0.05),子痫前期组胎盘VEGF的表达较对照组显著降低(P<0.05)。结论 AS、VEGF表达水平的变化均可能导致子痫前期的发病,而且可能相互影响。
Objective To detect the expression of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor (VEGF) in the placenta and explore its relationship with the pathogenesis of preeclampsia. Methods Thirty healthy maternal mothers were selected as the control group. Fifty-four patients with preeclampsia were selected as the control group. Immunohistochemistry was used to detect the expression of AS and VEGF in the placenta. Results The expression of placental AS in preeclampsia group was significantly higher than that in control group (P <0.05). The expression of placental VEGF in preeclampsia group was significantly lower than that in control group (P <0.05). Conclusions The changes of AS and VEGF expression may lead to the development of preeclampsia and may affect each other.