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以β-actin为内标，用逆转录—多聚酶链反应（RT－PCR）技术，研究c－metmRNA在32例肝癌组织、26例癌旁肝组织中的表达。结果表明，32例肝癌组织、26例癌旁肝组织中均有c-met基因表达（表达率100％），但肝癌c－met基因的表达值显著高于癌旁肝组织（46.75％±13．03％对2531％±11，03％，P＜0．001）。32例肝癌中c－met基因过度表达者有14例，统计分析发现c-met基因过度表达与肝细胞癌的分化程度及肝内转移有关。结果提示c－met基因在人肝细胞癌中高表达，并可能与肝癌的侵袭转移有关。
Using β-actin as an internal standard, reverse transcription-polymerase chain reaction (RT-PCR) was used to study the expression of c-met mRNA in 32 cases of hepatocellular carcinoma and 26 cases of adjacent liver tissues. The results showed that c-met gene expression was found in 32 cases of hepatocellular carcinoma and 26 cases of adjacent liver tissue (expression rate was 100%), but the expression of c-met gene in hepatocellular carcinoma was significantly higher than that in adjacent liver tissues (46.75%±13). .03% vs 2531% ± 11,03%, P < 0.001). There were 14 cases of c-met gene overexpression in 32 cases of liver cancer. Statistical analysis revealed that c-met gene overexpression was related to the differentiation of hepatocellular carcinoma and intrahepatic metastasis. The results suggest that c-met gene is highly expressed in human hepatocellular carcinoma and may be related to the invasion and metastasis of liver cancer.