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目的观察血管平滑肌脂肪瘤的病理学组织特点及免疫组化表达特征。方法光镜下进行组织学观察并结合免疫组化标记。结果血管平滑肌脂肪瘤主要由血管、平滑肌、脂肪三种成分构成,各成分所占比例多少不等,部分细胞有异型性,偶见核分裂像,免疫组化标记:Vimentin(+),Actin(+),HMB45(+),CD34(+),S-100部分(+),Desmin大部分(-)、小部分(+),EMA(-)。结论肿瘤中三种成分的比例、瘤细胞的形态及组织结构均有很大的变化,应与肾细胞癌、肉瘤等鉴别,细胞异型性及远处淋巴结转移均不能作为诊断恶性肿瘤的标准,HMB45阳性在诊断与鉴别诊断中有重要价值。
Objective To observe the pathological features and immunohistochemical features of angiomyolipoma. Methods Histological observation under light microscope combined with immunohistochemical markers. Results Angiomyolipoma mainly consisted of three components, vascular, smooth muscle and fat. The proportions of the components were different. Some cells were atypical and occasionally mitotic. The immunohistochemical markers Vimentin (+), Actin (+ ), HMB45 (+), CD34 (+), S-100 part (+), Desmin most part (-), small part (+), EMA (-). Conclusion The proportions of the three components of the tumor, the morphology and organization of the tumor cells all have great changes, which should be differentiated from the renal cell carcinoma and the sarcoma. Both the cell atypia and distant lymph node metastasis can not be used as the standard for the diagnosis of malignant tumors. HMB45 positive in the diagnosis and differential diagnosis of great value.