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细胞因子(cytokines,CK)是由T淋巴细胞、单核/巨噬细胞等产生的一大类信使蛋白/多肽类物质。CK的主要功能是起信息传递介质的作用,对细胞增殖、分化和分泌有刺激(上调)和抑制(下调)的调节功能。在类风湿关节炎(RA)等炎症性关节炎的发病中具有促炎、抑炎或刺激、抑制正负反馈的免疫调控作用。 1 细胞因子在RA发病中的调控作用 1.1 致炎细胞因子:这类CK的受体(R)均具有中和或弱抑制性抗炎作用。这类CK在RA等炎症性关节炎的发病中与RF等自身抗体及IC一样,起着重要作用。细胞因子致
Cytokines (CK) are a large group of messenger proteins / peptides produced by T lymphocytes, monocytes / macrophages. CK’s main function is to play the role of information transfer medium, cell proliferation, differentiation and secretion of stimulation (upregulation) and inhibition (down regulation). In the pathogenesis of inflammatory arthritis, such as rheumatoid arthritis (RA), it has proinflammatory, anti-inflammatory or stimulatory effects and inhibits the immunoregulatory effects of positive and negative feedback. 1 cytokines in the pathogenesis of RA regulation 1.1 proinflammatory cytokines: such CK receptor (R) has a neutralizing or weak inhibitory anti-inflammatory effect. Such CK in RA and other inflammatory arthritis in the pathogenesis of RF and other autoantibodies and IC, plays an important role. Cytokine induced