单次给药后,血药浓度自高峰下降后又再次上升形成第二乃至多个高峰的现象称为药时曲线的多峰现象(multiple-peak plenomenon),它的出现相当于一次“自体给药”,势必影响药物的作用强度及消除过程.卡马西平(carbamazepine,CBZ)的多峰现象国内只在家兔体内发现,国外在研究人体内CBZ及其物谢产物的药物动力学特征时,观察并报道了CBZ的多峰现象.我们在进行生物利用度试验时,也清楚地观察到CBZ在人体内c-t曲线上的多峰现象.1 材料与方法 After a single administration, the plasma concentration rises again from the peak and then rises again to form the second or even more peak phenomenon called the multi-peak plenomenon of the drug curve, which appears equivalent to a “autologous Drug ”is bound to affect the strength of the drug and the elimination process.Carbamazepine (CBZ) multimodal phenomenon only found in rabbits in vivo in foreign countries in the study of human CBZ and its metabolites when the pharmacokinetic characteristics , Observed and reported the multimodal phenomenon of CBZ.We also clearly observed in the bioavailability of CBZ in human ct curve multimodal phenomenon.Materials and methods