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目的:探讨奥美拉唑与甲氨蝶呤药物相互作用的机制和临床特点,为临床合理用药提供参考。方法:分析和评价临床1例9岁男孩发生奥美拉唑与甲氨蝶呤药物相互作用致甲氨蝶呤排泄延迟的病例,并以“质子泵抑制剂、甲氨蝶呤”为关键词,检索1990-2015年间中国期刊网全文数据库(CNKI)、万方数据库及Pubmed数据库的相关文献,进行统计分析。结果:该类药物相互作用的个案报道仅检索到10篇,其中2篇为国内报道。奥美拉唑可能延缓甲氨蝶呤的排泄,建议避免两者合用。结论:临床应高度重视奥美拉唑与甲氨蝶呤的药物相互作用,加强临床观察,确保用药安全。
Objective: To explore the mechanism and clinical features of the interaction between omeprazole and methotrexate, and to provide a reference for clinical rational drug use. Methods: To analyze and evaluate the clinical delay of methotrexate excretion caused by the interaction of omeprazole and methotrexate in a 9-year-old boy who was treated with “proton pump inhibitor and methotrexate” Keywords, and retrieve the relevant literature of CNKI, Wanfang Database and Pubmed database from 1990 to 2015 for statistical analysis. Results: Only 10 cases were found in the case reports of drug interactions, of which 2 were reported in China. Omeprazole may delay methotrexate excretion, it is recommended to avoid the combination of the two. Conclusion: Clinical should pay great attention to the drug interaction between omeprazole and methotrexate, to strengthen clinical observation and ensure the safety of medication.