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体内硒含量降低提示与严重的慢性病有关。用~(75)硒作研究,已证明十二指肠是人体吸收硒的主要场所。未经治疗的乳糜泻病人,小肠粘膜有异常,十二指肠和空肠受累最严重。作者测定了一组乳糜泻病人白细胞、血浆和全血的硒浓度,以了解病人体内的硒含量。 16例病人,年龄23～71(平均50.6)岁,从确立诊断时起病程平均7.7(2～19)年,全部病人临床状况良好,使用不含麦胶(gluten)的饮食。用氢化物生成和原子吸收分光光度测定法测定白细胞、血浆和全血的硒浓度。每例病人均选2名年龄、性别相配对的健康人作对照,对照组年龄21～74(平均49.5)岁。结果病人组与对照组比较,白细胞(P<0.001)、
Decrease in body selenium content suggests a serious chronic disease. With ~ (75) selenium for research, the duodenum has been proven to be the main site of human selenium absorption. Untreated celiac disease patients, small intestinal mucosa abnormalities, duodenum and jejunum most affected. The authors measured the selenium concentration in white blood cells, plasma and whole blood of a group of patients with celiac disease to understand the selenium content of the patient’s body. Sixteen patients, ages ranged from 23 to 71 (mean, 50.6) years of age, had an average duration of 7.7 (range, 2 to 19) years from the time of diagnosis, and all patients were in good clinical condition using gluten-free diet. Determination of selenium concentrations in leukocytes, plasma and whole blood using hydride generation and atomic absorption spectrophotometry. Each patient was selected 2 age and sex matched healthy people as a control group, the control group aged 21 to 74 (average 49.5) years old. Results Compared with control group, white blood cells (P <0.001)